Bioprocessing without the Guesswork

Biomass, pH, and Dissolved Oxygen Sensors and Automated Feeding for Cell Culture and Microbial Fermentations

Scientific Bioprocessing (sbi) is dedicated to developing cutting-edge digital technologies (such as sensors, actuators, and software) that simplify bioprocessing activities. Say goodbye to under-sampled and black box cultures and hello to real-time, non-invasive, automated, and online sensing. Our solutions feature sensors and software that:
 
  • Generate high-resolution growth curves in real-time to provide you with actionable insights.
  • Save you hours of manual, hands-on time required for alternative offline approaches.
  • Enable you to use nights or weekends for experiments.

Explore the Sensors & Actuators of the DOTS Platform

Automated, online, non-invasive biomass monitoring in shake flasks.
Cell Growth Quantifier (CGQ)

Non-invasive, real-time monitoring of biomass in shake flasks and bottles via backscattered light detection.

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Automated, online, non-invasive biomass monitoring in bioreactors.
CGQ BioR

Non-invasive and real-time monitoring of biomass in bioreactors via backscattered light detection.

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Automated feeding of liquids into shake flask cultures.
Liquid Injection System (LIS)

Automated and parallelized feeding of liquids in shake flasks.

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Monitor pH and dissolved oxygen (DO) in flow loops on perfusion bioreactors.
Flow Cell

Continuous monitoring of pH and dissolved oxygen (DO) in flow loops via optical sensors.

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Powered by DOTS Software

DOTS Software is your tool for easy handling of sensors, actuators, and bioprocess data, offering total control, from calibration to data collection.

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Trusted by Labs and Universities

SBI Success Table
"The CGQ provided accurate growth curves with very dense sampling intervals and gave us the opportunity to identify differences in growth behaviors."

- Prof. Dr. Lars Blank (RWTH Aachen)
RWTH Aachen
SBI Success Table
"The backscatter data we gathered here with the CGQ system clearly shows a match with another growth characterisation parameter, in this case with the oxygen transfer rate (OTR)."

- Frédéric Lapierre (HS München)
HS München
SBI Success Table
"The CGQ BioR system provides precise growth curves with a very dense sampling interval, freeing my team for tasks with higher added value"

- Dipl. Ing. Andreas Hoffman (Technical University Dresden)
Technical University Dresden
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"With the LIS, I was able to recreate typical bioreactor processes, like fed-batch cultivations, in shake flasks."

-Dr. Victor Pozzobon (Chaire de Biotechnologie, CentraleSupélec)
2017-05-24 Chaire Biotechnologie CS full_0-1
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"The CGQ BioR is well suited for monitoring biomass of cultivations with thermophilic organisms that require high temperatures and long fermentation times."

-Dipl. Ing. Robert Klausser (IBD Group, TU Wien)
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Biomass-based Feeding in Shake Flasks

Use the interconnectivity of sensors (CGQ) and actuators (LIS) within the new DOTS Software to enable feedback controlled feeding in your shake flask experiments. Set up your injection strategy based on your biomass threshold or growth rate and start feeding based on the specific needs of your culture.
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Resources

Customer Success Stories | Publications | Webinars

NEW

Improved Induction Screenings for a Successful Protein Production in Pichia pastoris

Pichia pastoris - Induction screening with an advanced biomass-based feeding application

Dr. Christina Dickmeis, a Senior Research Scientist at sbi, utilized biomass-based feeding to initiate methanol induction at the optimal time - once cell growth on the primary substrate (glycerol) was completed and sufficient biomass was generated, indicated by a reduction in growth rate.

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Want To Connect The DOTS In Your Bioprocessing?

CONTACT OUR TEAM